Classical Swine Fever Vaccine (IVRI-CSF-BS) Technology

Context: Secretary, Department of Agricultural Research and Education (DARE) and DG, ICAR, Dr. Trilochan Mohapatra and Secretary, Department of Animal Husbandry and Dairying (DAHD), Shri Atul Chaturvedi released the Live attenuated Classical Swine Fever Vaccine (IVRI-CSF-BS) Technology.


The Technology has been developed by ICAR -Indian Veterinary Research Institute (IVRI), Izatnagar. ABOUT THE VACCINE Classical Swine Fever Vaccine is safe, potent, does not revert to virulence and provide protective immunity from day 14 of the vaccination till 24 months studied so far. The vaccine has been tested on around 500 pigs at multiple locations. The new vaccine is ready for release and commercial production will be completed in less than a year. The vaccine would be the best choice for use in the CSF Control Programme (CSF-CP) already launched by Department of Animal Husbandry and Dairying (DAHD) (CSF-CP).  The vaccine virus has very high titre and lakhs of doses can be produced very easily in cell culture and country’s requirement can be easily fulfilled using this new vaccine.  Due to very high titre of vaccine virus, this vaccine would be the most economical CSF vaccine costing around less than Rs 2/- per dose as against Rs 15-25/- of lapinized CSF vaccine and Rs.30/dose (approx) for an imported Korean vaccine being used in the country. Besides, the new vaccine gives immunity for two years as compared to 3 to 6 months protection under the vaccines currently being used. The new vaccine will be part of the Government’s One Health Initiative and result in huge savings as it will nip the spread of the virus at animal stage so that it does not pass on to the human population.  WHAT ABOUT THE PREVIOUS VACCINES? lapinized CSF vaccine (Weybridge strainUK) is being used in India since 1964 for controlling the disease.The vaccine is produced by sacrificing large numbers of rabbits for each batch.   In order to do away sacrificing of rabbits and increase the productivity, IVRI had earlier developed a cell culture CSF vaccine by adapting the lapinized vaccine virus in cell culture. The technology has been transferred to M/s Indian Immunologicals, Hyderabad and Government of Punjab during 2016 and 2018, respectively.  ABOUT CLASSICAL SWINE FEVER (CSF) Classical swine fever (CSF) or hog cholera is a highly contagious disease of swine. CSF is one of the most important diseases of pigs causing high mortality with annual loss of approx. Rs.4.299 billion.The infectious agent responsible is a virus CSFV (previously called hog cholera virus) of the genus Pestivirus in the family Flaviviridae The incubation period of CSF ranges from 2 to 14 days, but clinical signs may not be apparent until after 2 to 3 weeks. Preventive state regulations usually assume 21 days as the outside limit of the incubation period. Animals with an acute infection can survive 2 to 3 months before their eventual death.

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